Serum Albumin Targeted, pH-Dependent Magnetic Resonance Relaxation Agents
نویسندگان
چکیده
منابع مشابه
Serum albumin targeted, pH-dependent magnetic resonance relaxation agents.
The objective of this work was the synthesis of serum albumin targeted, Gd(III)-based magnetic resonance imaging (MRI) contrast agents exhibiting a strong pH-dependent relaxivity. Two new complexes (Gd-glu and Gd-bbu) were synthesized based on the DO3A macrocycle modified with three carboxyalkyl substituents α to the three ring nitrogen atoms, and a biphenylsulfonamide arm. The sulfonamide nitr...
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D epartm ent of Radiology. University of California, San Francisco, California 94143, USA Z. Naturforsch. 41b, 1170—1177 (1986); received February 20, 1986 Bovine Serum Albumin, Gadolinium Complexes, Contrast Agents for NMR Imaging, Nitroxyls Bovine Serum Albumin (BSA) was spin labeled using the active esters 3 and 5 containing a nitroxyl radical to give the spin labeled BSA derivatives 4 and 6...
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The nuclear magnetic resonance line widths of water sorbed on solid bovine serum albumin have been determined as functions of temperature and water content of the albumin samples. The results indicate that, depending on its amount, the sorbed water may exist in three different states or arrangements. The first of these involves direct binding of water molecules to available polar groups on the ...
متن کاملTargeted Contrast Agents for Magnetic Resonance Imaging: Possibilities and Limitations
Introduction: Active targeting of contrast agents for magnetic resonance imaiinghas been &died by several investigators over the last years (1,2). The methods used include targeting via antibodies and receptors. Most of these studies have however been performed at non-clinical high field-strengths using highresolution imaging in anesthetised animals. The ability to detect the contrast enhancing...
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ژورنال
عنوان ژورنال: Chemistry - A European Journal
سال: 2012
ISSN: 0947-6539
DOI: 10.1002/chem.201103344